Inhibition of the extrinsic or intrinsic coagulation pathway during pneumonia-derived sepsis
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چکیده
منابع مشابه
extrinsic and intrinsic coagulation pathway, fibrinogen serum level and platelet count in hiv positive patients.
infection with human immunodeficiency virus (hiv) is a progressive condition which may cause endothelial dysfunction and liver damage leading to coagulopathy. with adventure of highly active antiretroviral therapy (haart), life expectancy has prolonged in hiv positive patients but several acquired immunodeficiency syndrome (aids)-related conditions such as coagulopathies are responsible for ass...
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Trophic factor deprivation (TFD)-induced apoptosis in sympathetic neurons requires macromolecular synthesis-dependent BAX translocation, cytochrome c (cyt c) release, and caspase activation. Here, we report the contributions of other intrinsic and extrinsic pathway signals to these processes. Sympathetic neurons expressed all antiapoptotic BCL-2 proteins examined, yet expressed only certain BH3...
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Apoptosis, as a programmed cell death (PCD) is essential for normal cell mechanism. The word “Apoptosis” derives from Greek language “απόπτωσις” and means trees shedding their leaves in autumn, which describes the "dropping off" or "falling off" of petals from flowers, or leaves from trees. This language imaginarily described the cell death triggered by physiological and pathological stimulatio...
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Formation of a fibrin clot is mediated by a group of tightly regulated plasma proteases and cofactors. While this system is essential for minimizing blood loss from an injured blood vessel (hemostasis), it also contributes to pathologic fibrin formation and platelet activation that may occlude vessels (thrombosis). Many antithrombotic drugs target key elements of the plasma coagulation mechanis...
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To study the interrelationships of the major human coagulation pathways, factor X activation in normal and various deficient human plasmas was evaluated when clotting was triggered by dilute rabbit or human thromboplastin. Various dilutions of thromboplastin were added to plasma samples containing 3H-labeled factor X, and the time course of factor X activation was determined. At a 1/250 dilutio...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2018
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00014.2018